طراحی و ساخت نانوداربست های کامپوزیتی پلی آنیلین/پلی کاپرولاکتون/ژلاتین و بررسی زیست سازگاری نانوفیبرها با کاربرد درمانی در بیماران

Introduction: Tissue engineering approach using the combination of stem cells and nanofibrous scaffolds has attracted the interest of research community for regeneration applications. Materials and Methods: In this study, PANi/PCL/Gel composite nanofibrous scaffold was fabricated by electrospinning. Plasma treatment technique was used for the surface modification of nanofibers. Contact angle technique and scanning electron microscopy (SEM) were used for characterization of electrospun nanofibers. Growth and proliferation of the cells as well as the biocompatibility of nanoscaffolds were evaluated by MTT assay. Results: The results of the contact angle technique showed the surface modification of electrospun nanofibrous scaffolds. The MTT results showed that the synthesized nanofibers did not have any toxic effect and promoted the growth and proliferation of fibroblast cells. SEM images confirmed the adhesion and biocompatibility of nanofibers. Conclusions: Our results suggested PANi/PCL/Gel electrospun nanofibers as a biocompatible composite for the regenerative medicine.